Inflammation :: science

fervorInflammation is the bodies normal response to injured tissues, although it croup sometimes lead to further tissue damage. It was first described around 30 BC by Celsius, as tumour (swelling), rubor (redness), calor (heat) and dolour (pain) although unnecessary secretion and loss of function are now commonly added. Inflammation is a response which has evolved to try and put things right in a change tissue, for example the pain and loss of function solelyow the tissue to heal easier whilst the heat and redness are caused by an increased blood flow to the tissue. (1) Inflammation occurs to control infection or injury, to eliminate pathogens, and to initiate healing and tissue repair. (2) An inflammatory pathology is usually indicated by the suffix -itis, such as in bronchitis, dermatitis, orchitis and enteritis, and loafer be either acute or chronic. (1) It is a non-specific defence and so the response of the body to a cut, burn, radiation, bacteria or virus are all very sim ilar. There are three basic stages to inflammation 1) Vasodilation and increased permeability of blood vessels, 2) Phagocyte emigration, and 3) Tissue repair (3) Unfortunately, sometimes inflammation dirty dog be the cause of, or increase the symptom severity of a disease, such as in Tuberculosis, leprosy and syphilis, which are persistent infections with low virulence micro-organisms Silicosis, atherosclerosis and radiation, prolonged exposure to potentially toxic agents. Rheumatoid arthritis and Hashimotos thyroiditis, autoimmune diseases (4) Body Acute inflammation occurs rapidly, within a few hours after the injury or infection occurs to which the inflammation is acting. Initially venules and arterioles dilate, causing hyperaemia. This then decreases and the vessels increase their permeability, allowing blood plasma and platelets into the tissue as serous exudate. this causes an oedema (excess fluid in the tissue). factor I in the exudate is converted to fibrin, which deposits itself to help to localise tissue damage and control bleeding. (2) Within an hour of the inflammation starting neutrophils, and then hours later monocytes, do on the scene. They leave the bloodstream by emigration (also known as diapedesis), dependent on chemotaxis they are attracted by microbes, kinins, complement and other neutrophils. These neutrophils attempt to annul the foreign bodies by phagocytosis. Any remaining dead phagocytes or damaged tissue after a few days becomes purulent exudate, or pus. This whitethorn be broken down in the body or may reach the surface of the body, but if it cannot be an abscess may be formed.